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the general answer for your questions do not pertain to qsynth (fluidsynth) or calf or any other instrument which implementation recognizes and reacts to modwheel events (MIDI CC#1) ootb.

what you may need is probably a MIDI filter/router that lets you configure which specific MIDI events gets dropped and/or re-routed; there several tools that may accomplish this and that; try qmidiroute for instance.

cheers