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for usb devices the best compromise you should get is:

these settings makes for a static i/o latency of 8 ms, which is pretty good and enough for most setups.

if you still get systematic xruns with the above, then you may start looking at the hardware itself or the device driver configuration (kernel/alsa module params, nrpacks, whatever).

please note that i don't know nothing about this device, so the are only wild tips.

also, if all else still falls short, consider a better tuned kernel eg. threadirqs boot option or preempt_rt patch + rtirq w/usb on top priority

cheers