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Calf suite and Carla do not work correctly in the AppImage, because they are plugins with dependencies on their own libraries.
In the AppImage the dependencies are not searched for in the system, but within the AppImage, which is basically a zip that recreates the "Unix" directories.

He solved it with ACE Fluidsynth (Ardorur Fluidsynth), which is a plugin without dependencies.

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A related reflection that is always present when there is a problem in Linux:

All these problems that Linux has with dependencies and so on are nothing more than a failed conception: Unix. The conception of Unix directories is a conceptual error that breaks the minimum requirements of Freedom.

For something to be free:

- It cannot have dependencies, but rather be self-sufficient.
- It must be defined and have identity. Unix dismembers the identity of applications into bin, lib, share....
- It must not be hierarchical but self-organized. In other words, there should be no ORDER, but ORGANIZATION.
In order, the structure is based on a hierarchy, on the organization of the properties of the individuals that make it up, relating to each other.

Etc, etc, etc.

We have free operating systems, based on UNIX, whose hierarchical conception violates freedom.

And of course, this inconsistency creates problems and headaches.
Everything that makes Linux difficult and cumbersome is caused by this hierarchical (and therefore failed) conception of UNIX.

Few people have realized this, or have expressed it publicly.

Others have realized the problems caused by the dictatorship of the UNIX hierarchy, although perhaps they have not realized the deep philosophical implications of why these problems arise, and it is because UNIX is the opposite of freedom.

An attempt to solve these problems is:
https://www.gobolinux.org/